Molecular machines in energy transduction, cellular signaling and defense processes

This BAG is composed of 6 working groups from 3 locations (university of Cologne, Bochum, Düsseldorf), the projects for this proposal are rather heterogeneous. Nonetheless, we are focusing on 6 main topics:
1.) proteins involved in transport processes, transporters or channels, either embedded in the membrane or acting in the cytosol (e.g. ABC transporters, fusion proteins, regulators)
2.) proteins involved in the immune system, pathogen invasion or defense/resistance processes (dehydratases, toxins, binding proteins)
3.) proteins involved or associated with diseases like cancer or developmental disorders (e.g. kinase, toxins)
4.) enzymes of putative industrial use to encounter increasing environmental pollution (e.g. transaminases, estereases)
5.) proteins involved in light harvesting, photosynthesis (C3/C4 pathways) and chromophore binding (e.g. synthases, photosensor domains)
6.) signaling or transport processes (e.g. ethylene, collagen) or fixation ([Fe-Fe]-hydrogenases)

本BAG由来自3个地点的6个工作组组成，这3个地点分别为科隆大学（University of Cologne）、波鸿（Bochum）与杜塞尔多夫（Düsseldorf）。本提案涵盖的项目异质性较强，尽管如此，我们仍聚焦于6大核心主题：
1.) 参与转运过程的蛋白质、转运蛋白或通道蛋白，可嵌入膜结构或在细胞质中发挥作用（例如ABC转运蛋白（ABC transporters）、融合蛋白、调控蛋白）
2.) 参与免疫系统、病原体入侵或防御/抗性过程的蛋白质（例如脱水酶、毒素、结合蛋白）
3.) 参与或关联癌症、发育障碍等疾病的蛋白质（例如激酶、毒素）
4.) 具备潜在工业应用价值、可用于应对日益严峻的环境污染的酶类（例如转氨酶、酯酶（estereases））
5.) 参与光捕获、光合作用（C3/C4途径）及生色团结合的蛋白质（例如合酶、光传感器结构域（photosensor domains））
6.) 参与信号转导或转运过程（例如乙烯、胶原蛋白），以及涉及[Fe-Fe]-氢酶（[Fe-Fe]-hydrogenases）的固定过程