mathys_et_al_2019_reprocessed_count_matrix

An single-cell object (SCE) with extension .qs of the Mathys et al., 2019 study data - https://doi.org/10.1038/s41586-019-1195-2 into Single-nucleus transcriptomic analysis and differential expression (DE) of Alzheimer’s disease. The data has been processed with scFlow -https://www.biorxiv.org/content/10.1101/2021.08.16.456499v2 . Note this includes the processed count matrix and associated metadata.The samples were single-nucleus transcriptomes from the prefrontal cortex of 48 individuals, 24 of which had high levels of β-amyloid and other pathological hallmarks of AD (‘AD-pathology’), and 24 individuals with no or very low β-amyloid burden or other pathologies (‘no-pathology’).

本数据集为Mathys等人2019年研究的单细胞对象（Single-Cell Object, SCE）文件，文件扩展名为.qs，对应DOI链接：https://doi.org/10.1038/s41586-019-1195-2，该研究聚焦阿尔茨海默病（Alzheimer’s disease, AD）的单细胞核转录组分析与差异表达（Differential Expression, DE）分析。数据集已通过scFlow工具完成预处理，预处理相关信息可参考预印本链接：https://www.biorxiv.org/content/10.1101/2021.08.16.456499v2。请注意，本数据集包含已预处理的计数矩阵与配套元数据。样本来源于48名个体的前额叶皮层单细胞核转录组，其中24名个体携带高水平β-淀粉样蛋白及其他阿尔茨海默病病理特征（下称「AD病理组」），剩余24名个体的β-淀粉样蛋白负荷及其他病理特征均为无或极低水平（下称「无病理组」）。