DATASET 1 _ Melanoma survival study

Supplementary Dataset 1 - Description
By means of bioinformatics analyses (UALCAN at https://ualcan.path.uab.edu/ and GEPIA2 at http://gepia2.cancer-pku.cn/#index) of online available datasets from cancer patients (TCGA collection), we generated a list of 3,498 gene whose expression was significantly different (p<0.05) between skin melanoma patients with high- or low-expression of genes which then were ordered according to the value of the S-Ratio calculated as described within the text of the manuscript. According to this experimental design, just as an example, the gene LHB in 1st position of the list has a S-Ratio = 0.3430 which means that patients with higher expression of LHB behave a median survival (1,096 days) about 3 times shorter than patients with lower LHB expression (3,195 days). Similarly, the gene CCL8 in 3,498th position of the list has a S-Ratio = 3,2473 which means that patients with higher expression of CCL8 have a median survival (6,225 days) 3.2 times longer than patients with lower CCL8 expression (1,917 days). Due to the large dimension of such dataset and the complexity of the required analyses, in the present study we focused only on the 25 genes showing the highest and those showing the lowest S-Ratio: a more complete analysis regarding the whole dataset of 3,498 genes is presently ongoing and will be object of a larger investigation.