A Metal-Free Reductive N‑Alkylation of Indoles with Aldehydes
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https://figshare.com/articles/dataset/A_Metal-Free_Reductive_N_Alkylation_of_Indoles_with_Aldehydes/14116636
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A simple metal-free method has been developed for the reductive N-alkylation of indoles employing aldehydes as the alkylating agent and inexpensive Et3SiH as the reductant. A wide range of aromatic and aliphatic aldehydes are viable substrates along with a variety of substituted indoles. In addition, the method was applied to a one-pot sequential 1,3-alkylation of a substituted indole and successfully demonstrated on a 100 mmol scale.
创建时间：
2021-02-25
