Additional file 1 of Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes

Additional file 1:Bovine poly-Q encoding genes. This file contains details of the bovine poly-Q encoding genes including gene symbols, gene and protein accessions, GLEAN5 accessions [19], the number, sizes and purities of poly-Q tracts encoded in each gene and corresponding annotation information for human orthologs. The reciprocal mapping highlighted human orthologs that map to more than one GLEAN5 model which may represent local assembly issues in the bovine genome assembly, incomplete gene models or inability to discriminate between paralogs. Also included are multiple accessions for some bovine genes which are used to discriminate between splice variants. Bovine genes containing poly-Q tracts that were not present in their human or murine orthologs are bolded. The purity of each tract was defined by a combination of G (for CAG) or A (for CAA) symbols followed by numbers. Genes that were assessed for polymorphic variation in the large cattle diversity panel are also listed with the number of identified alleles. (XLS 70 KB)

附加文件1：牛多聚谷氨酰胺（poly-Q）编码基因。本文件收录牛多聚谷氨酰胺编码基因的详细信息，包括基因符号、基因与蛋白质登录号、GLEAN5登录号[19]、各基因所编码的多聚谷氨酰胺序列的数量、长度与纯度，以及对应人类直系同源基因的注释信息。其中双向映射结果标注了匹配至多个GLEAN5模型的人类直系同源基因，此类情形可能源于牛基因组组装存在局部组装缺陷、基因模型不完整，或无法区分旁系同源基因。部分牛基因配有多个登录号，用于区分其不同剪接变体。将仅在牛基因中存在多聚谷氨酰胺序列，而其人类或小鼠直系同源基因中无该序列的牛基因以粗体标注。每一段多聚谷氨酰胺序列的纯度由G（对应CAG密码子）或A（对应CAA密码子）符号结合数字定义。本文件同时列出了在大型牛遗传多样性队列中被评估过多态性变异的基因，并标注了已鉴定的等位基因数量。（XLS格式，70 KB）