Enhanced Solubilisation of Fragrances in Solutions of Sugar Surfactants in Natural Deep Eutectic Solvents (NADES)

Natural deep eutectic solvents (NADES) represent a novel class of renewable and biodegradable solvents. We wish to investigate the self-aggregation behaviour of selected sugar surfactants (based on glucose, lactose etc.) in NADES. Our NADES of choice is a 1:2 molar mixture of choline chloride and urea, named "reline". Interestingly, such solutions could solubilise fragrance molecules such as terpenes and alcohols. The focus of this experiment lies in the solubilisation of multiple fragrance compounds and their synergistic effect. The unique combination of NADES, sugar surfactants and natural fragrance compounds results in a formulation of water-free biodegradable microemulsions. We see the possible application in cosmetics and in pharmaceuticals. With the help of small-angle neutron scattering, our objective is to shed light on the structure and size of these aggregates in NADES.

天然低共熔溶剂（Natural deep eutectic solvents, NADES）是一类新型可再生且可生物降解的溶剂。本研究旨在探究选定的以葡萄糖、乳糖等为原料的糖类表面活性剂在天然低共熔溶剂中的自聚集行为。本研究选用的天然低共熔溶剂为氯化胆碱与尿素以1:2摩尔比混合得到的体系，命名为"reline"。值得注意的是，该溶剂体系可有效溶解萜类、醇类等香料分子。本实验的核心研究内容为多种香料化合物的增溶效果及其协同作用机制。天然低共熔溶剂、糖类表面活性剂与天然香料化合物的独特组合，可制备得到无水分的可生物降解微乳液。该体系具备在化妆品与制药领域的应用潜力。借助小角中子散射（Small-Angle Neutron Scattering）技术，本研究的目标是阐明天然低共熔溶剂中上述聚集体的结构与尺寸特征。