EURL ECVAM Review of non-animal models in biomedical research - Autoimmune diseases

This highly curated knowledge base contains detailed descriptions of 183 non-animal models and recorded a sharp increase in the number of articles employing them between 2016 and 2018 compared to the 2014-2015 period. The majority of these models are based on the use of cells, particularly primary cells, and certain models are preferentially exploited for certain types of conditions, such as in the case of ex-vivo models like biopsies for skin diseases, and stem cells in the case of type 1 diabetes.本经严格人工甄选的知识库收录了183种非动物模型的详细说明，同时记录到：相较于2014-2015年周期，2016至2018年间采用此类模型的学术论文数量出现了显著增长。该类模型大多以细胞培养为基础，尤以原代细胞(primary cells)为主；部分模型则被优先应用于特定疾病场景，例如皮肤病研究可采用活检离体(ex-vivo)模型，而1型糖尿病相关研究则多采用干细胞模型。