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Enantioselective Synthesis of Nabscessin C

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NIAID Data Ecosystem2026-05-01 收录
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https://figshare.com/articles/dataset/Enantioselective_Synthesis_of_Nabscessin_C/24106632
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资源简介:
Enantioselective synthesis of nabscessin C (1), an aminocyclitol amide with antimicrobial activity, is reported. Starting from myo-inositol, (+)-nabscessin C was synthesized in 12 isolation steps. Desymmetrization of 2-deoxygenated 4,6-dibenzylinositol was achieved using lipase from porcine pancreas (PPL), and the stereochemistry was established by X-ray crystallography. This method has the potential for synthesizing other cyclitol-derived compounds.
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2023-09-08
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