Analysis of m6A modification-related regulators in Ara-C-resistant cells and parental cells in AML cells. Analysis of m6A modification-related regulators in Ara-C-resistant cells and parental cells in AML cells

Despite the current rapid development of targeted therapy and immunotherapy, chemotherapy is still the most common treatment for AML. However, relapse after chemotherapy remains a major obstacle to curative treatment of AML. Here, we found that the methyltransferase METTL14 was upregulated in drug-resistant AML cells, but overall m6A level was not significantly changed. Overexpression of METTL14 in AML cells increased resistance to chemotherapeutics, whereas downregulation of METTL14 increased sensitivity to chemotherapeutics. Overall design: Analysis of gene expression differences between parental cells and Ara-C-resistant THP1 cells