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Low-volume jet injection for intradermal immunization in rabbits
BACKGROUND: This study tested a low-volume (20–30 μl/20–30 μg DNA) jet injection method for intradermal delivery of a DNA vaccine. Jet injection offers the advantages of a needle-less system, low-cost
PubMed Central2002-05-23 更新50
UAG readthrough in mammalian cells: Effect of upstream and downstream stop codon contexts reveal different signals
BACKGROUND: Translation termination is mediated through an interaction between the release factors eRF1 and eRF3 and the stop codon within its nucleotide context. Although it is well known that the nu
PubMed Central2001-02-27 更新40
What you should know about PR3-ANCA: Evidence for the role of T cells in the pathogenesis of systemic vasculitis
The pathogenesis of systemic vasculitis is complex and is likely to involve many mechanisms. There is a growing body of evidence that T cells may contribute to the pathogenesis of anti-neutrophil cyto
PubMed Central2000-06-12 更新40
Fundamental deficiencies in the megatrial methodology
The fundamental methodological deficiency of megatrials is deliberate reduction of experimental control in order to maximize recruitment and compliance of subjects. Hence, typical megatrials recruit p
PubMed Central2001-01-30 更新50
Breast cancer research: where we are and where we should go
Breast cancer research: where we are and where we should go
PubMed Central2000-01-14 更新40
