A new 1D Zn(II) coordination polymer containing pyridinyl-imidazolyl ligand: crystal structure and protective effect on dermatitis by reducing the inflammatory level

A new coordination polymer of [Zn(bdc)(bimb)](DMF)(H₂O)₂ (<b>1</b>, H₂bdc = 1,4-dicarboxybenzene, bimb = 6,6'-bis(1H-benzo[d]imidazol-2-yl)-2,2'-bipyridine) has been successfully synthesized by reaction of Zn(NO₃)_2·6H₂O, H₂bdc and bimb in a mixed solvent of DMF and water at 80 °C for three days. Furthermore, an ultrasound synthesis technique has been implemented to reduce the particle size of the complex <b>1</b> to generate nanoscale <b>1</b> (denoted as nano <b>1</b>). We constructed the dermatitis mice model with DNFB-induction. The scoring index of the AD lesion in mice was evaluated after nano <b>1</b> treatment and the ELISA was used to measure the level of inflammatory medium after nano <b>1</b> exposure.

本研究成功合成了一种新型配位聚合物[Zn(bdc)(bimb)](DMF)(H₂O)₂（配合物1），其中H₂bdc为1,4-二羧基苯，bimb为6,6'-二(1H-苯并[d]咪唑-2-基)-2,2'-联吡啶；该配合物以六水合硝酸锌、H₂bdc与bimb为反应物，在N,N-二甲基甲酰胺（DMF）与水的混合溶剂中，于80℃下反应三日制得。此外，本研究采用超声合成工艺对配合物1进行粒径调控，成功制备得到纳米级配合物1（下称纳米1）。我们通过二硝基氟苯（DNFB）诱导构建了特应性皮炎（AD）小鼠模型，经纳米1干预后，对小鼠的AD皮损评分指标进行了评估，并采用酶联免疫吸附测定（ELISA）检测了纳米1处理后小鼠体内炎症介质的水平。