IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.

本提案中的IBS BAG团队涵盖IBS内部小组以及来自格勒诺布尔iRTSV/CEA、圣保罗莱迪朗斯CEA-Cadarache和布里蒂尼叙尔奥尔格IRBA的外部合作群组。我们围绕蛋白质的结构-功能关联展开研究，重点关注人类健康、生物技术及研究方法学三大方向。本项目中绝大多数课题均为MX-2329提案的延续，可划分为以下若干研究主题：宿主-病原体相互作用、新型药物靶点、基础细胞机制、膜蛋白、固有无序蛋白质（intrinsically disordered proteins）、生物技术应用以及研究方法学。部分课题采用整合研究策略，结合X射线晶体学（X-ray crystallography）、小角X射线散射（SAXS）、核磁共振波谱（NMR）与冷冻电镜（cryo-EM）等多种生物物理研究手段，旨在全面解析所研究生物大分子系统的复杂性。部分团队致力于连续晶体学（serial crystallography）及其技术发展，而ESRF-EBS已成为该领域的理想研究工具。