PMACS-106 (in paper)

<b>Project title</b>: PMACS-106<b>Grant Information:</b> AHA Grant 9TPA34910007, Regulatory role of pericardial macrophages in myocardial infarction<b>Relevant Citations:</b><b> </b><b>https://doi.org/10.1016/j.isci.2024.110244</b><b>Project Description:</b>· Animal Model: IL-33 induced pericarditis· Animal Age: 6-8 Weeks· Animal Sex:· Animal Strain: C57B6/J Lys^Cre or C57B6 Lys^CreGATA6^fl/fl· Number: 10 Mice· Groups:o 5 Lys^Creo 5 Lys^CreGATA6^fl/flo All received pericarditis injections· Experimental Conditions: All mice received IP injections of 1ug of IL-33 in 100uL of solution at day 0, 2, 4, 6 and 8. With each injection mice also received 100pmol/kg of IL-5. At day 10 mice sere sacrificed and hearts were processed for histology<b>Licenses: </b>N/A<br>

<b>项目名称</b>: PMACS-106
<b>资助信息</b>: 美国心脏协会（AHA）资助项目编号9TPA34910007，研究主题为「心包巨噬细胞在心肌梗死中的调控作用」
<b>相关引用文献</b>:<b> </b><b>https://doi.org/10.1016/j.isci.2024.110244</b>
<b>项目描述</b>:
· 动物模型：IL-33诱导型心包炎
· 动物周龄：6-8周
· 动物性别：未标注
· 动物品系：C57B6/J Lys^Cre 或 C57B6 Lys^CreGATA6^fl/fl
· 实验动物数量：10只小鼠
· 实验分组：
· 5只Lys^Cre组
· 5只Lys^CreGATA6^fl/fl组
· 所有小鼠均接受心包炎诱导注射
· 实验处理方案：所有小鼠于第0、2、4、6、8天经腹腔注射1μg IL-33（溶于100μL溶剂中），每次注射同时给予100pmol/kg剂量的IL-5。于第10天处死小鼠，取心脏进行组织学处理。
<b>授权协议</b>: 无