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TAK1-dependent checkpoint in dendritic cell survival regulates immune homeostasis and function

ChEBI2012-01-23 更新2026-07-21 收录

树突状细胞

TAK1信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-34417 数据链接链接失效反馈

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TAK1-dependent checkpoint in dendritic cell survival regulates immune homeostasis and function

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创建时间：

2012-01-23

兽用疫苗设计

树突状细胞

The chemokine (C motif) receptor 1 (XCR1) and its ligandXCL1 have been intensively studied in the mouse and human immune systems. Here, we determined the molecular characteristics of cattle XCR1 and X

NIAID Data Ecosystem140

STING mediates lupus via the activation of conventional dendritic cell maturation and plasmacytoid dendritic cell differentiation

自身免疫疾病机制

树突状细胞

BMDCs from WT, Fcgr2b-/- and Stinggt/gt were cultured, then stimulated with DMXAA for 3 and 6 hr. Cells were collected and lysed with 1 % IGEPAL CA-630, 0.5% TritonX-100, 150 mM NaCl, 50 mM Tris pH

NIAID Data Ecosystem40

Surface molecular expression on DC treated with different antigen.

免疫学

树突状细胞

Surface molecular expression on DC treated with different antigen.

NIAID Data Ecosystem30

Analysis of classical and migratory DC from the skin draining LNs of Flt3L treated mice and comparison to LPS treated DC from skin draining LN and peritoneal macrophages. Mus musculus

树突状细胞

转录组分析

Analysis of the differential transcriptome of DC derived from tissue vs. LN origin. The overall hypothesis is these data would reveal how migratory DC may be differently programmed from classical DC a

NIAID Data Ecosystem70

Reduced Type I Interferon response signature detected in dendritic cells from prediabetic NOD mice compared to C57BL/6.g7 and Rag KO.

自身免疫糖尿病

树突状细胞

Investigating type I interferon in prediabetic stage of DCs from NOD mice compared to C57BL/6.g7 and Rag KO mice. Overall design: RNAseq was used to study splenic cDC1, cDC2, pDC, moDC, and monocyte p

NIAID Data Ecosystem40

TAK1-dependent checkpoint in dendritic cell survival regulates immune homeostasis and function

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