Supplementary Material for: Quantitative Measurements of Motor Function in Alzheimer’s Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study

<b><i>Background:</i></b> This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer’s disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB). <b><i>Methods:</i></b> In this cross-sectional study, 49 patients with a diagnosis of AD (<i>n</i> = 17), FTD (<i>n</i> = 19), or DLB (<i>n</i> = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping. <b><i>Results:</i></b> Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Q-Motor values detected significant differences between AD and HC, while clinical ratings did not. <b><i>Conclusion:</i></b> Our results suggest that quantitative measurements provide more objective and sensitive measurements of motor dysfunction in dementia.

<b><i>研究背景：</i></b> 本研究探讨相较于临床评分，定量运动功能障碍测量在阿尔茨海默病（Alzheimer’s disease, AD）、额颞叶痴呆（frontotemporal dementia, FTD）及路易体痴呆（dementia with Lewy bodies, DLB）中的应用效能。
<b><i>研究方法：</i></b> 本项横断面研究共纳入49例确诊患者，其中阿尔茨海默病患者17例（<i>n</i> = 17）、额颞叶痴呆患者19例（<i>n</i> = 19）、路易体痴呆患者13例（<i>n</i> = 13）。所有受试者均接受认知测试、临床运动功能评估以及定量运动（Q-Motor）测试，测试内容包括旋前/旋后手部敲击、抓握提拉以及手指与足部敲击。
<b><i>研究结果：</i></b> 本研究结果显示，相较于健康对照（healthy controls, HC），AD、FTD与DLB患者的旋前/旋后运动及握力提拉评估的定量运动数值均显著升高。定量运动数值可检出AD组与健康对照组间的显著差异，而临床评分则无法检测到此类差异。
<b><i>研究结论：</i></b> 本研究结果表明，定量测量可为痴呆患者的运动功能障碍提供更为客观且灵敏的评估手段。