Monocyte-Specific Dysregulation of Cmpk1-Mediated Nucleotide Metabolism Drives Pyroptosis and Renal Ischemia-Reperfusion Injury

The precise etiology, intrinsic mechanisms, and effective interventions of renal ischemia-reperfusion injury are not sufficiently understood.To investigate the molecular basis, we carried out RNA-seq sequencing, single-cell RNA sequencing and metabolomic sequencing using two distinct mouse models: Sham and IRI.