G1P3 (IFI6), a Mitochondrial Localized Antiapoptotic Protein, Promotes Metastatic Potential of Breast Cancer Cells through mtROS. G1P3 (IFI6), a Mitochondrial Localized Antiapoptotic Protein, Promotes Metastatic Potential of Breast Cancer Cells through mtROS

G1P3 (IFI6) was associated with poor distance metastasis free survival (DMFS) in breast cancer cases. Therefore, we tested the hypothesis that G1P3-induced mitochondrial redox deregulation confers metastatic potentials in breast cancer cells. Our results demonstrate that coordinated action of multiple pathways elicited by G1P3-induced mtROS augment actin-containing migratory structures to promote breast cancer cell migration and invasion Comparative network analysis identified upregulation of antioxidant, acin remodeling, and EMT networks in G1P3 overexpressing MCF-7 cells. Overall design: Total RNA obtained from MCF-7 cells stably expressing vector or G1P3 were subjected to expression array to investigate the effect of G1P3 on gene expression in ER+ breast cancer cell line