Overlap between cavity pairs with significant correlations (CSCs) and known allosteric couplings.

The residue numbers of the functional (FS) and allosteric (AS) site residues were obtained from the literature (see main body of the article). In the fourth and fifth columns we mention whether there was any CSC with a cavity overlapping the FS and the other the AS: YES (at least one CSC existed), NO (no overlapping CSC was found), dashed line (——, functional information was lacking and the comparison could not be performed). Overlap between cavity pairs with significant correlations (CSCs) and known allosteric couplings.