Experimental peritoneal dialysis in Sprague-Dawley rats using conventional or low sodium dialysis fluids

During peritoneal dialysis, sodium is transferred in a paracellular fashion via inter-endothelial nanochannels from the blood plasma water to the dialysate and, initially, dialysate sodium concentrations are also diluted by free water transport across endothelial aquaporin-1 channels. These experiments were performed to evaluate the relative contributions of free water transport, convective- and diffusive transfer on dialysate sodium. Based on our findings, we devised a simple method to quantify ultrafiltration by analyzing the initial decline in dialysate sodium concentration, commonly referred to as the \"sodium dip.\", Experimental peritoneal dialysis was performed in healthy anesthetized 9 weeks old Sprague-Dawley rats using either 20 mL conventional (134 mmol/L) or low-sodium (125 mmol/L) peritoneal dialysis fluids utilizing a dwell time of 120 minutes. Blood plasma was analysed before and after dialysis to measure Na+, K+, Cl-. Ca++, glucose, urea, creatinine, and total CO2. 125I-albumin and 51Cr-EDTA were added to the dialysate to estimate intra-peritoneal volume and to assess small solute diffusion capacity, respectively. Samples (20 μL) of dialysate and blood were collected at multiple time-points during the dialysis session and analyzed on a gamma counter. All data in this dataset are unprocessed., , # Experimental peritoneal dialysis in Sprague-Dawley rats using conventional or low sodium dialysis fluids

## GENERAL INFORMATION

1. Title of Dataset: Experimental Peritoneal Dialysis in Sprague Dawley Rats: Low Sodium versus Conventional Dialysis Fluids

2. Author Information
A. Principal Investigator Contact Information
Name: Carl berg
Institution: Lund University, Medical Faculty
Address: Box 117, SE-221 00
Email:

3. Date of data collection March 2022 to April 2022

4. Geographic location of data collection: Lund, Sweden

5. Information about funding sources that supported the collection of the data: Funding by Lund University Medical Faculty Foundation grant YF 2020-YF0056, and The Inga-Britt and Arne Lundbergs Research Foundation (all to C.M. berg).

## SHARING/ACCESS INFORMATION

1. Licenses/restrictions placed on the data: -

2. Links to publications that cite or use the data: -

3. Links to other publicly accessible locations of the data: -

4. L...

在腹膜透析过程中，钠离子通过内皮细胞间纳米通道以细胞旁途径从血浆水转运至透析液；初始阶段，跨内皮水通道蛋白-1（aquaporin-1）通道的自由水转运还会稀释透析液钠离子浓度。本实验旨在评估自由水转运、对流转运与扩散转运对透析液钠离子的相对贡献。基于本研究结果，我们开发了一种通过分析透析液钠离子浓度初始下降（通常称为"钠下降（sodium dip）"）来量化超滤量的简便方法。

本实验以健康麻醉的9周龄斯普拉格-道利（Sprague-Dawley, SD）大鼠为对象，分别使用20mL常规（134mmol/L）或低钠（125mmol/L）腹膜透析液进行腹膜透析，留腹时长为120分钟。分别于透析前后采集血浆样本，检测钠离子（Na+）、钾离子（K+）、氯离子（Cl⁻）、钙离子（Ca²+）、葡萄糖、尿素、肌酐及总二氧化碳（total CO₂）水平。分别向透析液中添加¹²⁵I-白蛋白（125I-albumin）与⁵¹Cr-乙二胺四乙酸（51Cr-EDTA），用于估算腹腔内体积与评估小分子溶质扩散能力。在透析过程中的多个时间点采集透析液与血液样本（20μL），并使用γ计数器（gamma counter）进行检测分析。本数据集所有数据均未经过预处理。
# 斯普拉格-道利大鼠使用常规或低钠透析液的实验性腹膜透析

## 基本信息（GENERAL INFORMATION）
1. 数据集标题：斯普拉格-道利大鼠实验性腹膜透析：低钠与常规透析液对照
2. 作者信息
A. 主要研究者联系方式
姓名：卡尔·伯格（Carl Berg）
所属机构：隆德大学医学院
通讯地址：Box 117, SE-221 00
电子邮箱：（未提供）
3. 数据采集时间：2022年3月至2022年4月
4. 数据采集地点：瑞典隆德
5. 资助信息：本数据采集工作受隆德大学医学院基金会（项目编号YF 2020-YF0056）及英格-布里特与阿尔恩·隆德伯格研究基金会资助（均资助给C.M.伯格）。

## 共享/获取信息（SHARING/ACCESS INFORMATION）
1. 数据使用许可与限制：无
2. 引用或使用本数据集的出版物链接：无
3. 本数据集其他公开获取渠道链接：无
4. L...