Smooth muscle cell reprogramming in aortic aneurysms [RNA-Seq]

Smooth muscle cell TGFβ signaling is one of the primary drivers of smooth muscle cell maturation.  Inhibition of smooth muscle cell TGFβ signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed bulk RNAseq method to examine smooth muscle cell gene expression profile using fresh human tissues from normal aortic media smooth muscle cells and aneurysm aortic media smooth muscle cells. Examination of human aortic media smooth muscle cell gene expression in normal and aneurysm