Etiology of respiratory tract infections in the community and clinic in Ilorin, Nigeria

Objective: Recognizing increasing interest in community disease surveillance globally, the goal of this study was to investigate whether respiratory viruses circulating in the community may be represented through clinical (hospital) surveillance in Nigeria.

Results: Children were selected via convenience sampling from communities and a tertiary care center (n = 91) during spring 2017 in Ilorin, Nigeria. Nasal swabs were collected and tested using polymerase chain reaction. The majority (79.1%) of subjects were under 6 years old, of whom 46 were infected (63.9%). A total of 33 of the 91 subjects had one or more respiratory tract virus; there were 10 cases of triple infection and 5 of quadruple. Parainfluenza virus 4, respiratory syncytial virus B and enterovirus were the most common viruses in the clinical sample; present in 93.8% (15/16) of clinical subjects, and 6.7% (5/75) of community subjects (significant difference, p < 0.001). Coronavirus OC43 was the most common virus detec...

研究背景：鉴于全球社区疾病监测的关注度持续攀升，本研究旨在探讨尼日利亚的临床（医院）监测数据是否能够反映社区内流行的呼吸道病毒传播情况。研究结果：2017年春季，研究人员在尼日利亚伊洛林市，通过便利抽样法从社区及三级医疗中心招募了91名儿童作为研究对象。研究人员采集了受试者的鼻拭子样本，并采用聚合酶链式反应（polymerase chain reaction）进行检测。其中79.1%的受试者年龄不足6岁，该群体中有46人发生感染，感染率为63.9%。91名受试者中共计33人感染了一种或多种呼吸道病毒，其中10例为三重感染，5例为四重感染。临床样本中最常见的病毒为副流感病毒4型（Parainfluenza Virus 4）、呼吸道合胞病毒B型（Respiratory Syncytial Virus B）以及肠道病毒（Enterovirus），该类病毒在临床受试者中的检出率为93.8%（15/16），在社区受试者中的检出率仅为6.7%（5/75），组间差异具有统计学意义（p < 0.001）。冠状病毒OC43（Coronavirus OC43）是检出率最高的病毒……