The proposal is a continuation of the MX-2367 proposal : CryoEM-BAG France: Structural Biology using Cryo-EM in France

This proposal gathers Principal investigators from French Institutions that use cryo-EM to unravel the molecular mechanisms associated with various biological processes. Scientists belong to 8 centres that currently use Cryo-EM and have already used ESRF CM01 beamline. All the PIs in this application have already used CM01 during the past 2 years. Projects include the study of bacterial secretion systems (Bordeaux, Lyon, Paris), viruses and their infection mechanisms (Marseille), translation and its control (Bordeaux, Toulouse, Paris, Strasbourg), transcription (Strasbourg, Paris) and Macromolecular transport (Bordeaux, Lyon, Strasbourg). Note that there is been a change of PI at the Montpelliier center, with G; Labesse replacing P. Bon as a PI.

本提案汇集了法国各科研机构中利用冷冻电子显微镜（cryo-EM）阐明各类生物过程相关分子机制的首席研究员（Principal investigators，PI）。这些学者隶属于8个当前正在使用冷冻电镜、且已依托ESRF CM01光束线开展过研究的研究中心。本次申请涉及的所有首席研究员均在过去两年内使用过CM01光束线。其研究项目涵盖细菌分泌系统（波尔多、里昂、巴黎）、病毒及其感染机制（马赛）、翻译过程及其调控（波尔多、图卢兹、巴黎、斯特拉斯堡）、转录过程（斯特拉斯堡、巴黎）以及大分子运输（波尔多、里昂、斯特拉斯堡）。需注意的是，蒙彼利埃中心的首席研究员已发生人事变动，G·拉贝塞（G. Labesse）接替P·邦（P. Bon）出任该中心首席研究员。