Expression Data from Malignant Lymphoma

We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization.

本研究采用Affymetrix U133A基因芯片对220例成熟侵袭性B细胞淋巴瘤的RNA进行基因表达谱分析，其中包括符合世界卫生组织（WHO）所有标准的8例Burkitt淋巴瘤的核心组。通过对Burkitt淋巴瘤进行分子特征构建，并利用间期荧光原位杂交和基于阵列的比较基因组杂交技术检测到了染色体异常。