Additional file 3: Figure S2. of Molecular evolution of HIV-1 integrase during the 20Â years prior to the first approval of integrase inhibitors
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Relation between significant coupling and frequency of single/pairwise substitutions. a) Relation between the relative frequencies of substitution pairs within the MSA and the strength of their coupling values (only significant couplings are considered). b) Relation between the relative frequencies of single substitutions within the MSA and their absolute frequency in significant couplings. (ZIP 133Â kb)
显著耦合与单/成对替换频率间的关联。a) 多序列联配（Multiple Sequence Alignment, MSA）内替换对的相对频率与其耦合值强度间的关联（仅考虑显著耦合）。b) 多序列联配内单个替换的相对频率与其在显著耦合中的绝对出现频率间的关联。（ZIP 133 KB）
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创建时间：
2017-11-15
