MaHPIC Experiment HuB - Metabolomics analysis of human plasma from patients infected with Plasmodium falciparum and P.vivax for discovery of diagnostic markers of malaria

MaHPIC Experimental Description:
This study is based on archived plasma from samples collected between 2011 and 2014. Patients in Thailand who were infected with Plasmodium falciparum (30 subjects), P. vivax (30 subjects), co-infected with P. falciparum and P. vivax (22 subjects) were included, alongside two sets of non-malaria cases: non-malarial febrile illnesses (30 subjects) and healthy controls (30 subjects). Malaria subjects were enrolled under ethics research protocol TMEC 11-033, and non-malaria cases were enrolled under TMEC 14-025, both approved by the Ethical Review Committee of the Faculty of Tropical Medicine, Mahidol University, Thailand. All protocols and documentation were reviewed and sample shipments approved by the Emory IRB. Subjects were enrolled at the Ministry of Public Health (MOPH) Malaria Clinics in the Kanchanaburi and Tak provinces clinic between August 2011 and August 2014.

Within the MaHPIC, this project is known as ‘Experiment HuB’. Samples were obtained in collaborations with Jetsumon Prachumsri, Rapathborn Patrapuvich, Viravarn Luvira, Siriwan Rungin, Teerawat Saeseu, and Nattawan Rachaphaew at the Mahidol Vivax Research Unit and the Hospital for Tropical Diseases at Mahidol University. Untargeted metabolomics results were produced by Dean Jones at Emory University. Quantitative Metabolomics using the Biocrates platform results were produced by Dr. Regina Cordy and Manoj Khadka at Emory University. To access other publicly available results from HuB and other MaHPIC Experiments visit http://plasmodb.org/plasmo/mahpic.jsp. This page will be updated as datasets are released to the public.

Complete list of dataset contributors:
The MaHPIC Consortium, Jeremy D. DeBarry, Mary R. Galinski, Dean P. Jones, Manoj Khadka, Jessica C. Kissinger, Shuzhao Li, Viravarn Luvira, Regina Joice Cordy, Esmeralda VS Meyer, Mustafa Nural, Eric A. Ortland, Rapathborn Patrapuvich, Suman B. Pakala, Nattawan Rachaphaew, Teerawat Saeseu, Siriwan Rungin, ViLinh Tran, Jetsumon P. Sattabongkot, Karan Uppal
Please contact the Informatics Core with any questions / concerns / suggestions - [e-mail]

Linked Studies: Malaria Host-Pathogen Interaction Center (MaHPIC)