Transcriptomic changes mediated by ß-amyloid in human aortic endothelial cells (HAOEC)

We found that ß-amyloid accumulation is modulated in HAOEC cells by overexpression or blocking of lncRNA BACE1-AS, which in turn regulates both BACE1 mRNA and protein expression. BACE1 is key-enzyme in the synthesis of ß-amyloid from Amyloid Precursor Protein (APP). The transcriptomic changes mediated by 400nM ß-amyloid was investigated in HAOEC cells. Overall design: HAOEC cells stimulated or not with 400nM ß-amyloid