RNAs Interact with BRD4 to Promote Enhanced Chromatin Engagement and Transcription Activation. RNAs Interact with BRD4 to Promote Enhanced Chromatin Engagement and Transcription Activation

In this study, we provide a previously unrecognized convergence between eRNAs and histone acetylation in regulating the chromatin interactions and transcription functions of BRD4. Overall design: Exam

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Brd4 regulation of activity dependent transcription

Inhibition of Brd4 with Jq1 in neurons with or without BDNF stimulation Examination of the effects of Jq1 treatment on primary mouse cortical neurons

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Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation [RNA-seq]. Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation [RNA-seq]

Small molecule inhibitors of the acetyl-histone binding protein BRD4 have been shown to block cardiac fibrosis in pre-clinical models of heart failure (HF). However, the mechanisms by which BRD4 promo

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