Table_3_Association between malnutrition and contrast-associated acute kidney injury in congestive heart failure patients following coronary angiography.doc

BackgroundPrevious studies have shown that malnutrition is very common in patients with congestive heart failure (CHF) and is closely related to the occurrence of acute kidney injury. However, the relationship between malnutrition and contrast-associated acute kidney injury (CA-AKI) is unclear.Method and resultsWe obtained data from 842 patients who were diagnosed with CHF following coronary angiography (CAG) or percutaneous coronary angiography (PCI) and had follow-up information from January 2013 to February 2016. The patients were divided into 3 groups according to the Controlling Nutritional Status Score before CAG or PCI procedure (Group 1: Normal; Group 2: Mild Malnutrition; Group 3: Moderate to Severe Malnutrition). The main endpoint was CA-AKI. Univariate and multivariable logistic regression analyses were performed. 556 (60.0%) patients suffered from malnutrition before CAG or PCI. During a median follow-up of 2.1 years, A total of 49 (5.82%) patients developed CA-AKI. Additionally, 5 (1.75%), 26 (6.27%) and 18 (12.77%) events were documented in patients with normal, mild and moderate or severe malnutrition, respectively (p < 0.01). In multivariable-adjusted models, patients with malnutrition showed a significantly higher incidence of CA-AKI than those in the normal group.ConclusionMalnutrition is an independent risk factor for CA-AKI in CHF patients following CAG.

背景：既往研究表明，充血性心力衰竭（CHF）患者中营养不良现象十分普遍，且与急性肾损伤的发生密切相关。然而，营养不良与对比剂相关性急性肾损伤（CA-AKI）之间的关系尚不明确。方法与结果：本研究从2013年1月至2016年2月期间，对经冠状动脉造影（CAG）或经皮冠状动脉介入术（PCI）诊断为CHF且具有随访信息的842名患者进行了数据收集。根据CAG或PCI术前营养状况评分（营养状况控制评分）将患者分为三组（组1：正常；组2：轻度营养不良；组3：中度至重度营养不良）。主要终点为CA-AKI。进行了单因素和多因素逻辑回归分析。在CAG或PCI前，60.0%的患者存在营养不良。在平均随访2.1年的过程中，共有49名患者（5.82%）发生了CA-AKI。此外，在正常、轻度及中度或重度营养不良的患者中分别记录了5（1.75%）、26（6.27%）和18（12.77%）事件（p < 0.01）。在多因素调整模型中，与正常组相比，营养不良组CA-AKI的发生率显著升高。结论：在CAG后CHF患者中，营养不良是CA-AKI的独立危险因素。