Oral pigmentations in Laugier-Hunziker syndrome: a case report and review of diagnostic criteria

ABSTRACT Laugier-Hunziker syndrome (LHS) is a rare mucocutaneous disorder, of unknown etiology, characterized by multiple hyperpigmented macules, dispersed mostly on the oral mucosa, occasionally associated with longitudinal ridging of the nails. The diagnosis requires exclusion of other conditions, such as Addison's disease and Peutz-Jeghers syndrome. We report a case of a 34-year-old male patient, presenting with hyperpigmented macules on the lips, buccal mucosa and palate, as well as mild dark striations on toenails. After careful clinical and laboratorial investigations, the diagnosis of LHS was established. Given the lack of aesthetic complaints and symptoms, no treatment was necessary.

【摘要】劳吉-亨齐克综合征（Laugier-Hunziker syndrome, LHS）是一种病因不明的罕见皮肤黏膜疾病，以多发性色素沉着斑为主要特征，病变多分布于口腔黏膜，偶可伴发指甲纵嵴。该病的诊断需排除艾迪生病（Addison's disease）、普茨-杰格斯综合征（Peutz-Jeghers syndrome）等其他相关疾病。本文报告1例34岁男性患者，其临床表现为唇部、颊黏膜及腭部出现色素沉着斑，同时趾甲可见轻度深色条纹。经细致的临床与实验室检查后，确诊为劳吉-亨齐克综合征。鉴于患者无美学相关不适与临床症状，无需进行治疗。