FInnish National Protein Crystallography Consortium

The Finnish BAG encompasses 24 groups active in crystallography in Finland. The projects vary widely and include membrane proteins and protein complexes, other proteins involved in disease and antibiotics and drug development and discovery (endoplasmic regulation and protein secretion, ADP-ribosylation and several oncogenic proteins including kinases, biocatalysis) and several pathogen proteins and various enzyme targets and e.g. studies on phytochrome photoreceptors and complexes involved in actin dynamics regulation. Overall the BAG serves the national needs for highly variable projects, with different biological and biotechnological applications. Several project will benefit from microfocus beam lines and tunable wavelength options for phasing, others benefit from quick robust screening by MASSIF. Biology lab is needed for SAXS experiments.

芬兰BAG（Finnish BAG）涵盖了芬兰境内活跃于晶体学领域的24个研究小组。其研究项目覆盖范围广泛，涉及膜蛋白与蛋白质复合物、其他与疾病、抗生素及药物开发和发现相关的蛋白质（涵盖内质网调控与蛋白质分泌、ADP核糖基化反应以及包括激酶在内的多种致癌蛋白、生物催化方向），此外还包含多种病原体蛋白、各类酶靶点，例如植物色素光受体以及参与肌动蛋白动态调控的复合物相关研究。总体而言，BAG可满足国家在各类高多样性研究项目上的需求，这些项目涉及不同的生物学与生物技术应用场景。部分项目将受益于用于相位解析的微聚焦光束线与可调波长选项，另有部分项目则可通过MASSIF系统实现快速可靠的筛选。小角X射线散射（Small Angle X-ray Scattering，SAXS）实验则需要依托生物学实验室开展。