Long-term wheel-running and acute 6-h advances alter glucose tolerance and insulin levels in TALLYHO/JngJ mice

ABSTRACTStudies have shown a relationship between circadian rhythm disruptions and type-2 diabetes. This investigation examined the effects of circadian disruption (6-h phase advances) on the progression of diabetes in a type-2 diabetic mouse model –TALLYHO/JngJ – and whether wheel-running can alleviate the effects of the phase advances. 6-h advances alter fasting glucose, glucose tolerance and insulin production. Wheel-running reduced body mass, improved glucose tolerance and reduced insulin in TALLYHO/JngJ and alleviated some of the changes in diabetic symptoms due to 6-h advances. These results indicate that individuals with type-2 diabetes can benefit from physical activity and exercise can be a countermeasure to offset the effects of an acute phase advance.

摘要：已有研究表明，昼夜节律紊乱与2型糖尿病存在关联。本研究以TALLYHO/JngJ 2型糖尿病小鼠模型为对象，探究了昼夜节律紊乱（6小时时相前移）对糖尿病病程的影响，以及转轮运动是否能够缓解该时相前移带来的不良影响。6小时时相前移会改变小鼠的空腹血糖水平、葡萄糖耐量与胰岛素分泌功能。转轮运动可降低TALLYHO/JngJ小鼠的体质量，改善其葡萄糖耐量并降低胰岛素水平，同时缓解了6小时时相前移引发的部分糖尿病相关症状变化。本研究结果提示，2型糖尿病患者可从体力活动中获益，运动可作为一种干预手段，抵消急性时相前移带来的影响。