Kinase domain mutant of human Itk in complex with a covalently-binding inhibitor
收藏Protein Data Bank Japan2024-10-30 更新2026-03-21 收录
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Kinase domain mutant of human Itk in complex with a covalently-binding inhibitor Descriptor: 1-[(3S)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one, 1-[(3S)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one, GLYCEROL, ... Authors: Somers, D.O. Deposit date: 2013-05-02 Release date: 2013-08-21 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket. J.Biol.Chem., 288, 2013
创建时间：
2013-05-02
