Description of data and code for Williams et al "Spatial modulation of dark versus bright stimulus responses in the mouse visual system," Current Biology, 2021

<br>This data archive contains all code and data necessary to replicate each main text and supplementary figure and associated statistical comparisons in the following article:<br>Williams, B., Del Rosario, J., Muzzu, T., Peelman, K., Coletta, S., bichler, E. K., Speed, A., Meyer-Baese, L., Saleem, A. B. &amp; Haider, B. (2021). Spatial modulation of dark versus bright stimulus responses in the mouse visual system. Current Biology, 31, 1-8. <br>The data and code is compatible with Matlab 2018 or later.<br>The data archive is organized as self-contained subfolders corresponding to the results found in each main figure (e.g., folder 'F1' for results of Figure 1). Each subfolder contains code that loads the minimally processed data structures for replication of the published figures.<br>Abstract of associated publication: <br>A fundamental task of the visual system is to respond to both increases and decreases of luminance with action potentials (ON and OFF responses). OFF responses are stronger, faster, and more salient than ON responses in primary visual cortex (V1) of both cats and primates, but in ferrets and mice ON responses can be stronger, weaker, or balanced in comparison to OFF responses. These discrepancies could arise from differences in species, experimental techniques, or stimulus properties, particularly retinotopic location in the visual field, as has been speculated; however, the role of retinotopy for ON/OFF dominance has not been systematically tested across multiple scales of neural activity within species. Here, we measured OFF versus ON responses across large portions of visual space with silicon probe and whole-cell patch-clamp recordings in mouse V1 and lateral geniculate nucleus (LGN). We found that OFF responses dominated in the central visual field, whereas ON and OFF responses were more balanced in the periphery. These findings were consistent across local field potential (LFP), spikes, and subthreshold membrane potential in V1, and were aligned with spatial biases in ON and OFF responses in LGN. Our findings reveal that retinotopy may provide a common organizing principle for spatial modulation of OFF versus ON processing in mammalian visual systems. <br>Code repository can be found at https://doi.org/10.6084/m9.figshare.14872143<br>Post created on '02-Jul-2021 17:46:34'<br>

本数据存档包含复现下述论文中所有正文主图、补充图及相关统计对比所需的全部代码与数据：
Williams, B.、Del Rosario, J.、Muzzu, T.、Peelman, K.、Coletta, S.、Bichler, E. K.、Speed, A.、Meyer-Baese, L.、Saleem, A. B. 与 Haider, B.（2021）。小鼠视觉系统中明暗刺激响应的空间调制。《当代生物学》（*Current Biology*），31卷，第1-8页。
本数据与代码兼容Matlab 2018及更高版本。
本数据存档按独立子文件夹组织，每个子文件夹对应正文中某一主图的结果（例如，文件夹`F1`对应图1的结果）。每个子文件夹内含用于加载经最小化预处理的数据结构的代码，以复现已发表的图表。
相关论文摘要：
视觉系统的一项核心功能是通过动作电位（action potentials）分别对亮度升高与降低作出响应，即ON反应（ON response）与OFF反应（OFF response）。在猫与灵长类动物的初级视觉皮层（primary visual cortex, V1）中，OFF反应相较于ON反应更强、更快速且更显著；但在雪貂与小鼠中，ON反应相较OFF反应可表现为更强、更弱或二者平衡。这类差异可能源于物种、实验技术或刺激属性的不同——正如此前推测的，尤其是视觉野的视网膜拓扑位置差异；然而，跨物种内多尺度神经活动层面系统检验视网膜拓扑对ON/OFF反应优势的作用的研究仍属空白。本研究通过硅探针与全细胞膜片钳（whole-cell patch-clamp）记录，在小鼠V1及外侧膝状体（lateral geniculate nucleus, LGN）中测量了大范围视觉空间内的OFF与ON响应。我们发现，中央视觉野中OFF反应占主导，而外周视觉野中ON与OFF反应更为平衡。该发现在V1的局部场电位（local field potential, LFP）、锋电位（spikes）与阈下膜电位中均保持一致，且与LGN中ON/OFF反应的空间偏倚相契合。我们的研究揭示，视网膜拓扑或可为哺乳动物视觉系统中OFF与ON加工的空间调制提供统一的组织原则。
代码仓库可访问：https://doi.org/10.6084/m9.figshare.14872143
本条目创建于2021年7月2日17:46:34