BindingDB Entry 50018763: Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.

Small molecule binding data for protein BDNF/NT-3 growth factors receptor, High affinity nerve growth factor receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, NT-3 growth factor receptor, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Receptor-type tyrosine-protein kinase FLT3, and Tyrosine-protein kinase BTK, Uniprot O00329, P04629, P36888, P51617, Q06187, Q16288, Q16620, and Q9NWZ3

本数据集包含针对以下蛋白质的小分子结合数据：脑源性神经营养因子/神经营养因子3受体（BDNF/NT-3 growth factors receptor）、高亲和力神经生长因子受体（High affinity nerve growth factor receptor）、白细胞介素-1受体相关激酶1（Interleukin-1 receptor-associated kinase 1）、白细胞介素-1受体相关激酶4（Interleukin-1 receptor-associated kinase 4）、神经营养因子3受体（NT-3 growth factors receptor）、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基δ亚型（Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform）、受体型酪氨酸蛋白激酶FLT3（Receptor-type tyrosine-protein kinase FLT3）以及酪氨酸蛋白激酶BTK（Tyrosine-protein kinase BTK），对应UniProt编号为O00329、P04629、P36888、P51617、Q06187、Q16288、Q16620及Q9NWZ3