Diversity-Oriented One-Pot Synthesis to Construct Functionalized Chroman-2-one Derivatives and Other Heterocyclic Compounds

The asymmetric organocatalyzed diversity-oriented
one-pot synthesis
has been developed to construct chroman-2-one derivatives and other
heterocyclic compounds with excellent efficiency and stereoselectivity.
The reactions represent a challenging issue, since it altered the
inherent selectivity profiles exhibited by the substrates of 2-hydroxycinnamaldehyde 1 and trans-β-nitrostyrene 2, which was previously reported as the asymmetric oxa-Michael–Michael
cascade to generate chiral chromans. It should be noted that polycyclic
O,O-acetal-containing compounds, which are found in numerous natural
products and biologically interesting molecules, could also be achieved
in good yields with excellent enantioselectivity as a single diastereoisomer
with five continuous stereogenic centers.