THE ROLE OF DIFFUSION-WEIGHTED MRI OF PATIENTS WITH SPINE METASTASES

ABSTRACT Objective: The role of diffusion-weighted MRI in differential diagnostics and predicting the survival of patients with spine metastases was studied. Methods: The study included data from MRI and morphological studies of 23 patients with spine metastases. Results: The values obtained for the apparent diffusion coefficient (ADC) of tumors were compared with their histological type, cell density and Ki-67 proliferation index. The effect of ADC values on overall patient survival was also assessed. A reliable inverse correlation was established between ADC values and Ki-67 proliferation index for various types of spine metastases (r=-0.753, p=0.017). The dependence of ADC values and overall survival of patients with metastases in the spine is shown. Conclusion: The technique of diffusion-weighted MRI can be used as part of a comprehensive assessment in the preoperative planning of surgical treatment, and as a prognostic factor of overall survival for this group of patients. Level of Evidence II. Prognostic retrospective study,

摘要 目的：本研究探讨弥散加权磁共振成像（diffusion-weighted MRI）在脊柱转移瘤鉴别诊断及患者生存预后预测中的作用。方法：本研究纳入23例脊柱转移瘤患者的磁共振成像及形态学研究数据。结果：将肿瘤的表观弥散系数（apparent diffusion coefficient，ADC）测量值与其组织学类型、细胞密度及Ki-67增殖指数进行对比分析，并评估ADC值对患者总生存期的影响。本研究明确了不同类型脊柱转移瘤的ADC值与Ki-67增殖指数之间存在可靠的负相关关系（r=-0.753，P=0.017），同时证实了ADC值与脊柱转移瘤患者总生存期的相关性。结论：弥散加权磁共振成像技术可作为外科手术术前综合评估的组成部分，亦可作为该类患者总生存期的预后预测因子。证据等级II级，该研究为预后性回顾性研究。