Additional file 1 of Safety of beta-blocker and calcium channel blocker antihypertensive drugs in pregnancy: a Mendelian randomization study

Additional file 1: Table S1. Instrumental variables for systolic blood pressure. Table S2. Mendelian randomization results. Table S3. Colocalization results. Table S4. Mendelian randomization results in analyses considering females only. Table S5. Colocalization results in analyses considering females only. Table S6. Mendelian randomization results in analyses considering diastolic blood pressure in females only. Table S7. Colocalization results in analyses considering diastolic blood pressure in females only. Table S8. Colocalization results considering alternative priors. Table S9. MR-Egger results. Table S10. Weighted median results. Table S11. MR-PRESSO results. Table S12. Instrumental variables selected at the ADRB1 locus. Table S13. Instrumental variables selected at the CACNA1C locus. Table S14. Instrumental variables selected at the CACNA1D locus. Table S15. Instrumental variables selected at the CACNB2 locus. Table S16. Instrumental variables selected at the CACNB3 locus. Table S17. Instrumental variables selected at all calcium channel blocker gene regions.

附加文件1：表S1 收缩压的工具变量。表S2 孟德尔随机化（Mendelian randomization）分析结果。表S3 共定位（colocalization）分析结果。表S4 仅针对女性人群的孟德尔随机化分析结果。表S5 仅针对女性人群的共定位分析结果。表S6 仅针对女性人群的舒张压孟德尔随机化分析结果。表S7 仅针对女性人群的舒张压共定位分析结果。表S8 采用替代性先验的共定位分析结果。表S9 MR-Egger分析结果。表S10 加权中位数法分析结果。表S11 MR-PRESSO分析结果。表S12 筛选自ADRB1基因位点的工具变量。表S13 筛选自CACNA1C基因位点的工具变量。表S14 筛选自CACNA1D基因位点的工具变量。表S15 筛选自CACNB2基因位点的工具变量。表S16 筛选自CACNB3基因位点的工具变量。表S17 筛选自所有钙通道阻滞剂相关基因区域的工具变量。