Transfer of Chirality in the Rhodium-Catalyzed Chemoselective and Regioselective Allylic Alkylation of Hydroxyarenes with Vinyl Aziridines

By
taking advantage of chirality-transfer strategy, a chemo- and
regioselective allylic alkylation of naphthols and phenols with vinylaziridines
provides an atom-economic and efficient method for the synthesis of
enantioenriched 2-vinyl-2-arylethylamine derivatives. Use of readily
available starting materials, a broad substrate scope, high selectivity,
mild reaction conditions, as well as versatile functionalizations
of the aromatic ethylamine products make this approach very practical
and attractive.