Supplementary Material for: Patient-Reported Outcomes and Aesthetic Results after Immediate Breast Reconstruction Using Human Acellular Dermal Matrices: Results of a Multicenter, Prospective, Observational NOGGO-AWOGyn Study

<b><i>Background:</i></b> With the increased use of acellular dermal matrices (ADMs) in implant-based breast reconstructions (IBBRs), the evaluation of patient-reported outcomes becomes more important. <b><i>Methods:</i></b> Patients who underwent an immediate human ADM-assisted, submuscular IBBR were included in this noninterventional, multicenter, prospective cohort study. Patients with primary reconstruction (cohort A) and patients with a revision surgery after capsular fibrosis (cohort B) were followed up for 12 months after surgery. Quality of life (EORTC BR-23) and patient and surgeon satisfaction scores (1 [“very satisfied”] to 6 [“not satisfied”]) with the outcome and the aesthetic result evaluated by 2 independent, external experts were assessed. <b><i>Results:</i></b> Eighty-four patients were enrolled in the study. The mean patient satisfaction score was 2.1 ± 0.8, with higher satisfaction in cohort B (<i>p</i> = 0.041). The score did not change significantly during the follow-up (<i>p</i> = 0.479). The mean satisfaction score of the surgeons was 2.0 ± 0.7; it was also higher in cohort B (<i>p</i> = 0.016) and showed no changes over time (<i>p</i> = 0.473). The mean aesthetic result was 2.2 ± 0.7. 92.9% of the patients completed at least 1 quality of life questionnaire. Body image and sexual functioning increased during follow-up. One year after surgery, the mean scores were 77.2 ± 22.5 and 44.7 ± 27.3, respectively. <b><i>Conclusion:</i></b> The level of satisfaction among patients and surgeons and the score of the aesthetic result were constantly high among patients after ADM-assisted IBBR. Higher satisfaction scores could be observed after revision surgery caused by capsular fibrosis (cohort B) compared to primary reconstruction (cohort A). Quality of life increased during the first year after surgery.

**背景**：随着脱细胞真皮基质（acellular dermal matrices, ADMs）在乳房植入物重建术（implant-based breast reconstructions, IBBRs）中的应用日益增多，患者报告结局的评估愈发重要。
**方法**：本研究为非干预性、多中心前瞻性队列研究，纳入了接受即刻人类脱细胞真皮基质辅助肌下乳房植入物重建术的患者。将患者分为两组：行一期乳房重建者（队列A）和因包膜挛缩行修复手术者（队列B），所有患者术后均接受为期12个月的随访。本研究评估了患者报告的生活质量（采用EORTC BR-23量表）、患者与术者对手术结局的满意度评分（评分范围1分[“非常满意”]至6分[“不满意”]），以及由2名独立外部专家评估的美学效果评分。
**结果**：本研究共纳入84例患者。患者总体满意度评分的平均值为2.1±0.8，队列B的满意度更高（p = 0.041）；随访期间满意度评分无显著变化（p = 0.479）。术者满意度评分的平均值为2.0±0.7，队列B的评分同样更高（p = 0.016），且随时间无明显变化（p = 0.473）。美学效果评分的平均值为2.2±0.7。92.9%的患者至少完成了1份生活质量问卷。随访期间，患者的身体意象与性功能评分均有所提升；术后1年时，两项评分的平均值分别为77.2±22.5与44.7±27.3。
**结论**：接受脱细胞真皮基质辅助乳房植入物重建术的患者，其术后的患者与术者满意度水平、美学效果评分均持续处于较高水平。与一期乳房重建患者（队列A）相比，因包膜挛缩行修复手术的患者（队列B）的满意度评分更高。术后1年内，患者的生活质量呈提升趋势。