Paris Rive-Gauche BAG: from structure to drug design

Our BAG was created in 2006 to federate well-established structural biology laboratories from south Paris. At present, several projects are investigated by different teams from 5 Institutes: (1) I2BC (Institut de Biologie Inte#grative de la Cellule), (2) IBPC (Institut de Biologie Physico-Chimique), (3) INSERM (Institut National de la Sante# et de la Recherche Me#dicale), (4) LBPA (Laboratoire de Biologie et Pharmacologie Applique#e) and (5) CiTCoM (CiblesTherapeutiques et Conception de Medicaments, ex-name LCRB). Our research area focuses on many important biological systems involved in human pathology or infectious diseases, including molecular chaperones, DNA recombination, RNA maturation, ribosome biogenesis, telomerase assembly, bacterial toxins, malaria disease, neurodegenerative disease, drugs resistance and cell-signalling.

本BAG于2006年成立，旨在整合巴黎南部久负盛名的结构生物学实验室。目前，来自5家机构的不同团队正开展多项研究项目：(1) I2BC（细胞整合生物学研究所，Institut de Biologie Intégrative de la Cellule）；(2) IBPC（生物物理化学研究所，Institut de Biologie Physico-Chimique）；(3) INSERM（法国国家健康与医学研究院，Institut National de la Santé et de la Recherche Médicale）；(4) LBPA（应用生物学与药理学实验室，Laboratoire de Biologie et Pharmacologie Appliquée）；(5) CiTCoM（治疗靶点与药物设计中心，原名为LCRB，Cibles Thérapeutiques et Conception de Médicaments）。本研究方向聚焦诸多与人类病理学或感染性疾病相关的重要生物系统，涵盖分子伴侣、DNA重组、RNA成熟、核糖体生物发生、端粒酶组装、细菌毒素、疟疾、神经退行性疾病、耐药性以及细胞信号传导等领域。