Anemia and related nutrient deficiencies after Roux-en-Y gastric bypass surgery: a systematic review and meta-analysis

Objective: To obtain a pooled risk estimate on the long-term impact of anaemia and related nutritional deficiencies in patients receiving Roux-en-Y gastric bypass (RYGB) surgery. Design: Systematic review and meta-analysis. Data sources: MEDLINE, EMBASE and Cochrane databases were searched to identify English reports published before 16 May 2014. Eligibility criteria: Articles with case numbers >100, follow-up period >12 months, and complete data from both before and after surgery were selected. Outcomes of interest were changes in baseline measurements of proportion of patients with anaemia, by haemoglobin, haematocrit, ferritin, iron, vitamin B12 and folate levels. Data collection and analysis: Two reviewers independently reviewed data and selected six prospective and nine retrospective studies with a total of 5909 patients. A random effect model with inverse variance weighting was used to calculate summary estimates of outcomes at 6, 12, 24 and 36 months postoperatively. Result...

研究目的：获取接受Roux-en-Y胃旁路术（Roux-en-Y gastric bypass, RYGB）的患者中，贫血及相关营养缺乏的长期影响的合并风险估计值。
研究设计：系统评价与Meta分析。
数据来源：检索MEDLINE、EMBASE及Cochrane数据库，筛选2014年5月16日前发表的英文文献。
纳入标准：纳入病例数＞100例、随访周期＞12个月且包含手术前后完整数据的研究。
关注结局：基于血红蛋白、血细胞比容、铁蛋白、铁、维生素B12及叶酸水平评估的贫血患者占基线比例的变化情况。
数据收集与分析：由2名研究者独立筛选文献，最终纳入6项前瞻性研究与9项回顾性研究，总计纳入5909例患者。采用逆方差加权随机效应模型，计算术后6、12、24及36个月时各结局指标的合并估计值。
结果……