New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples.

A magnetic solid-phase extraction (MSPE) procedure on the newly synthesized magnetic β-cyclodextrin functionalized with toluene diisocyanate (TDI) as a linker and was further modified with bio-polymeric spores of sporopollenin (MSp-TDI-βCD) was developed for the extraction of nonsteroidal anti-inflammatory drugs (NSAIDs) namely indoprofen (INP), ketoprofen (KTP), ibuprofen (IBP) and fenoprofen (FNP) from water samples prior to their HPLC-DAD determination. The newly synthesised MSp-TDI-βCD was comprehensibly characterized using FT-IR, XRD, SEM-EDX, BET and VSM analyses. The separation of selected NSAIDs on MSp-TDI-βCD from aqueous solution was simply achieved by applying an external magnetic field via a permanent magnet. The MSPE parameters affecting extraction performance i.e., sorbent dosage, sample volume, extraction and desorption time, type of organic eluent and volume and solution pH were investigated and optimized. The proposed method showed linear range between 0.5 - 500 ng/mL, ...

本研究开发了一种磁固相萃取（magnetic solid-phase extraction, MSPE）方法，以甲苯二异氰酸酯（toluene diisocyanate, TDI）为连接臂，将新型合成的磁性β-环糊精经孢粉素生物聚合物孢子修饰后得到MSp-TDI-βCD作为吸附剂，用于从水样中萃取非甾体抗炎药（nonsteroidal anti-inflammatory drugs, NSAIDs），包括吲哚洛芬（indoprofen, INP）、酮洛芬（ketoprofen, KTP）、布洛芬（ibuprofen, IBP）与非诺洛芬（fenoprofen, FNP），后续采用高效液相色谱-二极管阵列检测器（HPLC-DAD）进行测定。对所合成的新型MSp-TDI-βCD吸附剂，采用傅里叶变换红外光谱（Fourier transform infrared spectroscopy, FT-IR）、X射线衍射（X-ray diffraction, XRD）、扫描电子显微镜-能谱仪（scanning electron microscope-energy dispersive X-ray spectroscopy, SEM-EDX）、BET比表面积分析法（Brunauer-Emmett-Teller, BET）以及振动样品磁强计（vibrating sample magnetometer, VSM）进行了全面表征。仅需通过永磁体施加外磁场，即可简便实现水溶液中目标非甾体抗炎药在MSp-TDI-βCD上的分离。本研究对影响萃取性能的磁固相萃取参数，即吸附剂用量、样品体积、萃取与解吸时间、有机洗脱剂种类与体积以及溶液pH值，进行了系统考察与优化。所建立的方法线性范围为0.5~500 ng/mL，……