UK Midlands BAG

The UK Midlands BAG consists of groups located at the Universities of Birmingham, Leicester, Warwick, Nottingham, Keele, and Wolverhampton. We represent a diverse spectrum of research interests, from microbiology, cancer biology, blood disorders, immunology to fundamental biological processes such as membrane transport, DNA repair and mechanisms of enzyme catalysis. Our groups use X-ray crystallography in conjunction with other structural biology, biophysical and biochemical techniques to elucidate molecular mechanisms of protein-protein and protein-ligand interactions. Our cooperation in this block allocation group is mirrored by the consortium of institutions that are stakeholders in the Midlands Regional CryoEM Facility at the University of Leicester.

英国中部区块分配小组（UK Midlands BAG）由分布于伯明翰大学、莱斯特大学、华威大学、诺丁汉大学、基尔大学及沃尔夫汉普顿大学的多个研究团队构成。本研究群组的研究兴趣覆盖多元领域，涵盖微生物学、癌症生物学、血液疾病、免疫学，以及膜运输、DNA修复、酶催化机制等基础生物学过程。各团队结合X射线晶体学（X-ray crystallography）与其他结构生物学、生物物理及生物化学技术，以阐明蛋白质-蛋白质与蛋白质-配体相互作用的分子机制。我们在该区块分配小组中的协作模式，与莱斯特大学中部区域冷冻电镜（CryoEM）设施的利益相关方机构联盟的协作体系相互呼应。