Márton-et-al-Exploring the impact of the host defense peptide Pap12-6 on the immune response and epithelial integrity in chicken-derived ileal explant cultures.

In the present study, chicken ileal explant cultures were used to examine the effects of the HDP Pap12-6 on enteral immune state and tight junction proteins. The peptide was applied solely at 25 and 50 µg/ml concentrations (PAP-low and PAP-high, respectively) and administered in inflammatory conditions evoked by polyinosinic-polycytidylic acid (Poly I:C, 50 µg/ml), at the same doses (PI:C+PAP-low and PI:C+PAP-high, respectively).The present dataset belongs to the following original research article: https://doi.org/10.1016/j.psj.2025.105376.

本研究采用鸡回肠外植体培养物，探究宿主防御肽（Host Defense Peptide, HDP）Pap12-6对肠内免疫状态与紧密连接蛋白的影响。该肽仅以两种浓度单独施用：25 μg/ml与50 μg/ml，分别记为PAP-low组与PAP-high组；同时在由聚肌胞苷酸（polyinosinic-polycytidylic acid, Poly I:C, 50 μg/ml）诱导的炎症条件下，以相同剂量给药，分别记为PI:C+PAP-low组与PI:C+PAP-high组。本数据集源自下述原创研究论文：https://doi.org/10.1016/j.psj.2025.105376.