Additional file 1 of Lipid reprogramming induced by the TFEB-ERRα axis enhanced membrane fluidity to promote EC progression

Additional file 1: Figure S1. The flow chart of study participants. Abbreviation: APO-A, a polipoprotein A; APO-B, a polipoprotein B; BMI, Body Mass Index; CA125, Cancer antigen 125; CHOL, Cholesterol; Con, Control; EC, Endometrial cancer; ERRα, Estrogen-Related Receptor α; FIGO, Federation International of Gynecology and Obstetrics; HDL, High-Density Lipoprotein; IHC, Immunohistochemistry; IRS,Immunoreactive Score; LDL, Low-Density Lipoprotein; LNM, Lymph Node Metastasis; LC/MS, Liquid Chromatography Mass Spectrometry; PC, Phosphatidylcholine; PE, Phosphatidylethanolamine; TAG, Triacylglycerol; TG, Total Triglyceride; TFEB, transcription factor EB. Figure S2. The ROC cruve of PC (18:1/18:2) +HCOO, PC (32:2) +H, HDL and CA125. Figure S3. Hypothesis diagram of lipid reprogramming in EC cells modulated by TFEB-ERRα axis. Table S1. The overlapped lipids between TFEB and ERRα over-expressing. Table S2. Significant proteins derived from omics analysis.

补充材料1：图S1。研究受试者流程图。缩写说明：APO-A（apolipoprotein A），载脂蛋白A；APO-B（apolipoprotein B），载脂蛋白B；BMI（Body Mass Index），身体质量指数；CA125（Cancer antigen 125），癌抗原125；CHOL（Cholesterol），胆固醇；Con（Control），对照组；EC（Endometrial cancer），子宫内膜癌；ERRα（Estrogen-Related Receptor α），雌激素相关受体α；FIGO（Federation International of Gynecology and Obstetrics），国际妇产科联盟；HDL（High-Density Lipoprotein），高密度脂蛋白；IHC（Immunohistochemistry），免疫组织化学；IRS（Immunoreactive Score），免疫反应评分；LDL（Low-Density Lipoprotein），低密度脂蛋白；LNM（Lymph Node Metastasis），淋巴结转移；LC/MS（Liquid Chromatography Mass Spectrometry），液相色谱-质谱联用；PC（Phosphatidylcholine），磷脂酰胆碱；PE（Phosphatidylethanolamine），磷脂酰乙醇胺；TAG（Triacylglycerol），三酰甘油；TG（Total Triglyceride），总甘油三酯；TFEB（transcription factor EB），转录因子EB。图S2：PC(18:1/18:2)+HCOO、PC(32:2)+H、高密度脂蛋白与癌抗原125的ROC曲线。图S3：TFEB-ERRα轴调控子宫内膜癌细胞脂质重编程的假说示意图。表S1：TFEB与ERRα过表达样本间的重叠脂质。表S2：组学分析得到的显著差异蛋白。