Additional file 1 of Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

Generation of EpiEdit mice derived from ESCs via tetraploid complementation. Table S2. Generation of EpiEdit mice by transient expression of epigenome editing factors. Table S3. Generation of EpiEdit mice by stable expression of epigenome editing factors. Table S4. gRNAs and primers for mouse experiment. Table S5. gRNAs and primers for human experiment.

通过四倍体补偿法（tetraploid complementation）制备源自胚胎干细胞（Embryonic Stem Cells，ESCs）的EpiEdit小鼠。表S2：通过瞬时表达表观基因组编辑因子生成EpiEdit小鼠。表S3：通过稳定表达表观基因组编辑因子生成EpiEdit小鼠。表S4：小鼠实验所用的向导RNA（gRNAs）与引物。表S5：人类实验所用的向导RNA（gRNAs）与引物。