Pleiotropy matrices for eGenes and eQTLs

The Phenotype eQTL overlap sheet has names of phenotypes in columns TraitX and TraitY. The number of eQTLs identified for TraitX and TraitY are given in eQTLsX and eQTLsY. The column, Common, is the number of eQTLsY that are in eQTLsX. Ratio is Common divided by eQTLsX.<br>The Phenotype eGene overlap sheet has names of phenotypes in columns TraitX and TraitY. The number of eQTLs identified for TraitX and TraitY are given in eGenesX and eGenesY. The column, Common, is the number of eGenesY that are in eGenesX. Ratio is Common divided by eGenesX.<br>In the Control eGene overlap sheet, all 7,917 eGenes were pooled together and randomly assigned to phenotypes so that each phenotype in the control matrix had the same number of eGenes as its corresponding phenotype in the eGene matrix. The pairwise ratios of common eGenes among the phenotypes were calculated as done in the eGene matrix. 1000 different null datasets were constructed in this manner and the mean matrix was calculated. The Ratio column is the mean of 1000 null sets between phenotypes in columns TraitX and TraitY.表型表达数量性状基因座（eQTL）重叠表的列TraitX与TraitY中存储了表型名称。列eQTLsX与eQTLsY分别记录了为TraitX和TraitY鉴定得到的eQTL数量。Common列表示同时存在于eQTLsX中的eQTLsY的数量，Ratio值为Common除以eQTLsX的比值。 表型表达关联基因（eGene）重叠表的列TraitX与TraitY中存储了表型名称。列eGenesX与eGenesY分别记录了为TraitX和TraitY鉴定得到的eQTL数量。Common列表示同时存在于eGenesX中的eGenesY的数量，Ratio值为Common除以eGenesX的比值。 在对照eGene重叠表中，研究人员将全部7917个eGene合并汇总后随机分配至各表型，使得对照矩阵中每个表型的eGene数量与eGene矩阵中对应表型的eGene数量保持一致。按照与eGene矩阵相同的方法，计算各表型间共有的eGene的成对比值。通过该方式构建1000套独立的零假设数据集，并计算得到其均值矩阵。Ratio列即为TraitX与TraitY列中对应表型间的1000套零假设数据集的比值均值。