GWAS summary statistics from: Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression

Here, we provide genome-wide summary statistics from our study: Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression (TRD). We studied the genetic architecture of TRD, defined as major depressive disorder (MDD) with adequate antidepressant trial followed by electroconvulsive therapy (ECT), representing a severe subset of TRD cases. The data include results from genome-wide association meta-analyses of TRD risk (2,062 TRD cases vs. 441,037 healthy controls) and treatment resistance within MDD (2,062 TRD cases vs. 38,544 non-TRD cases), encompassing both common variant and copy number variation (CNV) analyses. A file named "md5sum" is provided to enable verification of data integrity.Citation: Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J; FinnGen; Estonian Biobank Research Team; Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y. Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression. Mol Psychiatry. 2025 Jun 26. doi: 10.1038/s41380-025-03084-z. Epub ahead of print. PMID: 40571737.

本研究公开了针对治疗抵抗性抑郁症（treatment-resistant depression, TRD）的全基因组关联荟萃分析及罕见拷贝数变异分析的全基因组范围汇总统计量。
本研究聚焦TRD的遗传结构，该类TRD被定义为经足量抗抑郁药物治疗后仍需接受电抽搐治疗（electroconvulsive therapy, ECT）的重性抑郁障碍（major depressive disorder, MDD）患者，属于TRD病例中的严重亚型。
本数据集包含两项分析结果：一是TRD风险相关的全基因组关联荟萃分析（2062例TRD患者 vs 441037名健康对照），二是MDD患者群体中治疗抵抗性相关的全基因组关联荟萃分析（2062例TRD患者 vs 38544例非TRD患者），涵盖常见变异与拷贝数变异（copy number variation, CNV）两类分析内容。
本数据集附带名为"md5sum"的文件，用于验证数据完整性。
参考文献：Xiong Y, Krebs K, Jermy B, Karlsson R, Pasman JA, Nguyen TD, Gong T, Kowalec K, Rück C, Sigström R, Jonsson L, Clements CC, Hörbeck E, Andersson E, Bäckman J; FinnGen研究团队; 爱沙尼亚生物样本库研究团队; Ganna A, German J, Sullivan PF, Landén M, Lehto K, Lu Y. 治疗抵抗性抑郁症的全基因组关联荟萃分析及罕见拷贝数变异分析. 分子精神病学（Mol Psychiatry）. 2025年6月26日提前在线出版. DOI: 10.1038/s41380-025-03084-z. PMID: 40571737.