Supplementary Material

Supplementary Table 1. The transition
pattern of the 7 common uremic indicators between case and control periods
before hemodialysis initiation (N = 1,079). “No” means the indicator does not
reach the predefined cutoff values shown on the first column, whereas “Yes”
means the opposite. The order of these indicators follows the frequency of
“no-to-yes” from high to low.

Supplementary
Table 2. Biochemical
characteristics in control and case periods (N = 1,079)

Supplementary
Table 3. Distribution
of 30-day and daily doses of furosemide in control and case periods and based
on the three dialysis timing groups.

Supplementary
Figure 1. Flow diagram of patient selection.

Supplementary Figure 2.
Case-crossover study design and timing of exposure measurements including
uremic indicators and medications in relation to hemodialysis initiation.