Text S1 - The Role of Multiple Marks in Epigenetic Silencing and the Emergence of a Stable Bivalent Chromatin State

We have relegated the mathematical details of the model in Text S1. Analytical solution of the model in the mean-field limit is presented therein, and the nature of the different phases is summarized. We also compare related models with fewer or more biochemical interactions (parameters) in order to establish that the interactions we have considered are minimal for the engineering design criteria of epigenetic silencing. We also elaborate on Sir perturbations and Sas2 perturbations and discuss the nature of bifurcations/crossovers observed in the phase space.
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